Search results for " perampanel"

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Perampanel and Visuospatial Skills in Children With Epilepsy

2021

Introduction: Perampanel (PER) is a non-competitive AMPA glutamate receptor antagonist approved for focal and generalized seizures as add-on therapy. PER does not seem to negatively affect the cognitive profile in children and adolescents, but its influence on visuospatial abilities is still to be assessed. The aim of our study was to assess visuospatial skills through a standardized neuropsychological evaluation in adolescents taking PER for 12 months.Methods: Our sample included 46 adolescents aged 12–18 years with focal and generalized drug-resistant epilepsy already in therapy with one or two antiseizure medications. Changes in visuospatial perception and memory were assessed by the Rey…

medicine.medical_specialtygenetic structuresAudiologybehavioral disciplines and activitiesSpatial memory050105 experimental psychology03 medical and health sciencesPerampanelchemistry.chemical_compound0302 clinical medicineperampanelchildrenmedicineadverse effects children perampanel tolerability visuospatial memory0501 psychology and cognitive sciencesGlutamate receptor antagonisttolerabilityRC346-429Original Researchbusiness.industry05 social sciencesNeuropsychologyCognitionExecutive functionsNeurologychemistryVisuospatial perceptionAdjunctive treatmentadverse effectsvisuospatial memoryNeurology. Diseases of the nervous systemNeurology (clinical)business030217 neurology & neurosurgery

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